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KMID : 0370219600050010031
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Yakhak Hoeji
1960 Volume.5 No. 1 p.31 ~ p.36
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Studies on Enteric Coating Bases. Ⅰ
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金壽億/Kim, Soo Uck
池達顯/文正鉉/李金貞/Chi, Dal Hyun/Mun, Jung Hyun/Lee, Kum Jung
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Abstract
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The importance of enteric coating technique among the pharmaceutical firms has recently risen very significantly. This study of enteric coating bases was made in order to determine the most suitable bases and dusting powders. Materials and equipment used in this experiment are shown in table 1 and kinds of euteric coating bases aud their formulas are shown in table 2.
The evaluation of the suitability for enteric coating bases aud dusting powder was made by disintergration test after measuring the thickness of the enteric coated layer as shown in the tables 4 and 5.
Based on the results of this study, the tase D(shellac 20 Gm, anhydrous lanoline 5 Gm, 96% alcohol 75 ㎖) and the base E (shellac 10 Gm, cetyl alcohol 10 Gm. acetone 80 ㎖) are selected among the 8 kinds of bases studied in a preliminary test and it was found that Mg-stearate and Ca-stearate were in most suitable dusting powders among the 6 kinds studied for the bases D and E.
Further study on baes D and E was carried out by varying the proportions of the materials which were the orginal constituents of bases D and E.
According to the result of this further study shown in table 6, the shellac 15 Gm cetyl alcohol 5 Gm Acetone 80 ㎖ of base E is recommended as the most suitable dusting powder.
(Received November 25, 1959)
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